Genes First™ · Muscle & Skeletal

Stay strong and mobile for life.

Muscle, collagen, joints and bone strength are all influenced by your DNA. Build a body that lasts.

  • Understand your muscle & recovery genes
  • Protect joints, collagen and bone density
  • Training & nutrition guidance built for you

One test · Results in 2–3 weeks · HSA/FSA eligible

Stay strong and mobile
Muscle & skeletal

The pathways behind strength and recovery.

With 3X4, you can move beyond trial-and-error and focus on the genetic factors that shape your strength, joint comfort, and mobility outcomes.

  1. Muscle Health

    Your genes can influence how efficiently you build, repair, and maintain muscle tissue. These insights help tailor training, recovery, and nutrition for better strength outcomes.

  2. Collagen & Joints

    Genetic variation can affect connective tissue quality and joint resilience. Understanding this pathway helps you support flexibility, stability, and long-term movement comfort.

  3. Bone Health

    Bone turnover, density maintenance, and structural support are partly gene-driven. Your results can guide smarter decisions to help protect skeletal strength over time.

Every pathway result explains what it means for you. Your Genes First™ Plan then turns your top three pathways into food recommendations you can act on right away.

Why 3X4

Muscle & Skeletal Health, Tailored to You

Your body does not recover, rebuild, or adapt exactly like anyone else. 3X4 gives you the genetic context behind movement, repair, and resilience so you can:

Train With Better Precision

Understand how your genes influence muscle response and recovery so you can align training intensity, volume, and rest with your biology.

Reduce Wear and Tear

Identify genetic tendencies that may affect connective tissue resilience and joint comfort to make better movement and load-management choices.

Support Lifelong Mobility

Use targeted nutrition and lifestyle actions to protect bone strength and preserve performance, whether you are an athlete or focused on healthy aging.

How it works

From a cheek swab to a plan that's actually yours.

01 / 03

Swab at home

No blood, no clinic, no appointment. Register your kit, swab your cheek for 30 seconds, and mail it back, shipping's on us.

5 minutes, start to finish

02 / 03

We read your DNA

Our CAP & CLIA-certified lab analyzes 35 pathways across 10 key health areas, the systems approach practitioners use, not a consumer novelty panel.

Results in 2–3 weeks

03 / 03

Get your plan in the app

Your results live in the 3X4 Health app, plus a downloadable report, with food, lifestyle and supplement guidance built for your genes, not the average person's.

Yours for life, DNA doesn't change

From the community

What people do with their results.

“Knowing my genetics lets me train smarter, not harder. I've already tweaked my diet and lifestyle, and the results? I feel stronger, more energized, and my performance has been next level. And this is just the beginning!”
Brian Mazza@brianmazza
“The 3X4 Genetics test was really helpful for me! It helped me to not have injuries, so it's so important. I think it's one of the main things as a professional player and, of course, every single person.”
Carlos Vela@carlosv11_
“I truly believe in 3X4 and I'm fully integrating the test into my program to make my job easier! The more I learn, the more I'm blown away by everything this test has to offer!”
Kim Lyons@trainerkimlyons
“With this test, I've unlocked the genetic edge to push my ultra-endurance limits—tailoring my nutrition, training, and recovery with pinpoint accuracy has been a total game-changer.”
Matt Johnson@mattjohnson_
“Can't wait to see how 3X4's genetic insights can help me make better personal health choices, and offer another layer of context to guide the individualized coaching we already do at ALTIS.”
Stu McMillan@altis
“I was able to verify some of the things I had already figured out through experimentation that worked for me. And I was able to learn a few more things that I could add to my diet and my supplementation that would actually take my fitness to the next level.”
Kaz
Questions, answered

What people ask about

Who is this Muscle & Skeletal Health testing best for?

It is valuable for anyone focused on strength, injury prevention, healthy aging, or improving recovery. Whether you train regularly or simply want to preserve mobility, your results help tailor your next steps.

What kind of DNA test do you perform?

We utilize a simple, painless cheek swab test that examines key areas of your genome to reveal tailored lifestyle recommendations based on your genetic variants.

Can this help reduce joint and overuse issues?

The test is not diagnostic, but it identifies genetic tendencies related to connective tissue and recovery. These insights can support smarter training, load management, and lifestyle choices.

How accurate is at-home genetic testing?

3X4 genetic tests use advanced genomic technologies ensuring high accuracy in identifying genetic markers.

When will I get the test results?

Our lab processes samples in 2-3 weeks on average, and results are delivered digitally to your online account on the same day they are completed.

How will my DNA be protected?

Your genetic privacy is 100% guaranteed. All information and connections are encrypted using SSL, and we follow best practices that align with HIPAA and POPI standards. For more details, read our Privacy Policy.

Is the 3X4 test eligible for HSA/FSA reimbursement?

Yes, it is eligible for HSA / FSA.

How can I use my HSA/FSA debit card?

You would use it in the same way you would use a credit card when paying; simply enter the needed card info. If this does not work, simply pay for the test with your normal credit card, download the invoice/receipt, and submit it for reimbursement.

The cost of guessing

Another year of trial-and-error isn't free.

The 3X4 test is a one-time cost. Guessing is the expensive option.

$1,000s

spent on supplements your body may not even use

Years

of diets and routines built for someone else's biology

Every day

feeling 'off' without knowing why, or what to change

Get my DNA kit

One test · Results in 2–3 weeks · HSA/FSA eligible