Genes First™ · Weight

Stop fighting your metabolism. Start working with it.

Your genes shape appetite, fat storage and how you burn energy. 3X4 reveals your weight blueprint so your plan finally fits your biology.

  • See whether you're a fast or slow metaboliser
  • Know if appetite or fat-storage genes work against you
  • Food & lifestyle guidance matched to your DNA

One test · Results in 2–3 weeks · HSA/FSA eligible

Stop fighting your metabolism.
Weight & metabolism

The pathways behind how you burn energy.

  1. Pro-Inflammatory Fat

    Learn how your body processes and stores fat, and how you can optimize your diet for better energy management.

  2. Energy Expenditure

    See how your genetics impact resting and active calorie expenditure. Get tailored tips to boost metabolism.

  3. Fat Storage

    Genes shape how your body uses stored fat for exercise fuel. Understand the most effective way to exercise for your unique physiology.

  4. Appetite

    Regulate your appetite with insights into your genetic tendencies influencing hunger/satiety signals and overeating risk.

Every pathway result explains what it means for you. Your Genes First™ Plan then turns your top three pathways into food recommendations you can act on right away.

Why 3X4

Change the Game with 3X4

Our DNA testing maps out your genetics, providing a foundation of insights about your body. With this information, your nutritionist can build tailored nutrition and lifestyle recommendations, empowering you to:

Move with Intention

Discover the types of exercise that work best for your body and make fitness enjoyable.

Outsmart the Plateau

Support your hormone pathways with targeted strategies based on your DNA, and watch the pounds start melting.

Prevent Weight Regain

Understand your risk factors for weight regain and develop a tailored plan to stay on track.

One test, every area

Your report also covers all 10 health areas.

Cellular Health

Your cellular health underpins your energy, resilience, and overall well-being. You can take targeted steps to optimize energy production, reduce cellular damage, and support long-term health.

Brain Health

Your brain health drives emotional balance, focus, and memory. Based on your results, you’ll gain practical recommendations on nutrition, habits, and stress-management techniques to support emotional stability, mental clarity, and lasting brain adaptability.

Heart & Vascular Health

Your heart and circulation depend on finely tuned genetic controls. With these insights, you can make smarter choices around diet, movement, and lifestyle to support lifelong heart and circulation health.

Weight

Your body-weight biology is shaped by multiple genetic levers. Knowing where your unique levers lie lets you fine-tune nutrition, exercise, and lifestyle tactics to work with rather than against your biology for sustainable weight management.

Hormone Health

Hormones influence everything from mood and metabolism to sleep and stress resilience. Insight into your genetic predisposition helps you prioritize nutrition, lifestyle, and environmental choices that promote optimal hormone regulation and reduce the risk of imbalances.

Blood Sugar Regulation

Steady glucose and insulin are key to energy and metabolic health. Armed with your Glucose & Insulin profile, you can adopt targeted strategies, like meal timing, nutrient support, and daily movement to stabilize blood sugar and enhance long-term metabolic wellness.

Muscle & Skeletal Health

Your muscles, joints, and bones depend on genetic factors that influence strength, flexibility, and repair. These results help you identify areas where you may be more prone to tissue breakdown, connective damage, or lower bone turnover, so you can take proactive steps to strengthen your structure, reduce injury risk, and stay active for life.

Sensitivities

Your body’s reactions to common compounds can affect energy, digestion, and overall wellbeing. These insights empower you to adjust your diet and environment, avoiding or moderating specific exposures, to reduce discomfort and support overall wellness.

Nutrients

Genes affect how you absorb, use, and transport key vitamins and fats. Knowing where you have higher needs or lower efficiency lets you tailor your diet and supplementation to support energy, immunity, brain health, and cellular function.

Activity

Your genetics shape how your body moves, builds resilience, and recovers. Across five activity pathways, injury, endurance, power, recovery, and training response, you'll see how to train smarter, protect against injury, and recover better for your unique biology.

How it works

From a cheek swab to a plan that's actually yours.

01 / 03

Swab at home

No blood, no clinic, no appointment. Register your kit, swab your cheek for 30 seconds, and mail it back, shipping's on us.

5 minutes, start to finish

02 / 03

We read your DNA

Our CAP & CLIA-certified lab analyzes 35 pathways across 10 key health areas, the systems approach practitioners use, not a consumer novelty panel.

Results in 2–3 weeks

03 / 03

Get your plan in the app

Your results live in the 3X4 Health app, plus a downloadable report, with food, lifestyle and supplement guidance built for your genes, not the average person's.

Yours for life, DNA doesn't change

From the community

What people do with their results.

“Knowing my genetics lets me train smarter, not harder. I've already tweaked my diet and lifestyle, and the results? I feel stronger, more energized, and my performance has been next level. And this is just the beginning!”
Brian Mazza@brianmazza
“The 3X4 Genetics test was really helpful for me! It helped me to not have injuries, so it's so important. I think it's one of the main things as a professional player and, of course, every single person.”
Carlos Vela@carlosv11_
“I truly believe in 3X4 and I'm fully integrating the test into my program to make my job easier! The more I learn, the more I'm blown away by everything this test has to offer!”
Kim Lyons@trainerkimlyons
“With this test, I've unlocked the genetic edge to push my ultra-endurance limits—tailoring my nutrition, training, and recovery with pinpoint accuracy has been a total game-changer.”
Matt Johnson@mattjohnson_
“Can't wait to see how 3X4's genetic insights can help me make better personal health choices, and offer another layer of context to guide the individualized coaching we already do at ALTIS.”
Stu McMillan@altis
“I was able to verify some of the things I had already figured out through experimentation that worked for me. And I was able to learn a few more things that I could add to my diet and my supplementation that would actually take my fitness to the next level.”
Kaz
Questions, answered

What people ask about

How accurate is the 3X4 test?

Our test analyzes gene results known to influence metabolism, fat storage, and nutrition absorption to provide highly accurate insights into how your body responds to diet and exercise.

What kind of DNA test do you perform?

We utilize a simple, painless cheek sample collection test that examines key areas of your genome to reveal tailored lifestyle recommendations based on your genetic variants.

Can this help me if other diets have failed?

Absolutely, DNA-guided meal plans and exercise routines are aligned with your genetic predispositions, helping your results feel more sustainable than conventional, one-size-fits-all approaches.

Do you provide the full diet & workout plans?

No, the test provides tailored insights and actionable steps so your nutritionist and trainer can fine-tune existing plans to better fit your genetic makeup.

When will I get the test results?

Our processing centre samples in 2-3 weeks on average and results are delivered digitally to your online account that same day they are completed.

How will my DNA be protected?

Your genetic privacy is 100% guaranteed. All information and connections are encrypted using SSL and we follow best practices that align with HIPAA and POPI standards. For more details read through our Privacy Policy.

Is the 3X4 test eligible for HSA/FSA reimbursement?

Yes, it is eligible for HSA / FSA.

How can I use my HSA/FSA debit card?

You would use it in the same way you would use a credit card when paying, simply enter the needed card info. If this does not work, simply pay for the test with your normal credit card, download the invoice/receipt and submit that for reimbursement.

The cost of guessing

Another year of trial-and-error isn't free.

The 3X4 test is a one-time cost. Guessing is the expensive option.

$1,000s

spent on supplements your body may not even use

Years

of diets and routines built for someone else's biology

Every day

feeling 'off' without knowing why, or what to change

Get my DNA kit

One test · Results in 2–3 weeks · HSA/FSA eligible