One test.
A lifetime of
answers

Most genetic tests hand you raw data and leave you to sort it out. 3X4 turns how your genes work together into a plain-English guide for the 10 health areas that drive how you feel. Not predictions. Not ancestry.

Get my DNA kit → See a sample report

9,000+

Practitioners trust 3X4

HSA / FSA

Eligible

Free shipping

On every order

Real people, real reasons

Whatever brought you here, your DNA meets you there.

Performance, balance, parenting, or the long game, 3X4 reads the same genes and turns them into a plan that fits the reason you came.

Jenna
“Turns out my DNA had the answers I was missing.”
Leslie
“I wasn’t dealing with multiple health issues — I was dealing with one story I didn’t know how to read yet.”
Grace
“How cool would it be if our bodies came with an instruction manual?”
Candice
“You don’t look at the symptoms — you look upstream.”
Brian Mazza
“It’s not about guessing anymore — it’s about knowing.”
Dr Perlmutter
“When we understand our uniqueness, we’re really a leg up for longevity.”
Dr Becky
“Your body runs on entire biological pathways, not isolated genes.”

Used in clinic, taken at home

The test 9,000+ clinicians trust.

3X4 is not a consumer-genetics product looking for a market. It is the test medical doctors, registered dietitians, and nutrigenomics specialists run with their patients, and on themselves, every day. Adopted in clinic before it ever reached your inbox.

3X4 is used in clinic across all 50 states. Darker shading marks where adoption runs highest.

9,000+Practitioners

50US states

4Countries

CLIA-certified

Run by a clinical-grade partner lab

Your sample is processed by a CLIA-certified laboratory, the same accreditation standard your physician's bloodwork is held to.

25+ years of research

Built on peer-reviewed nutrigenomics

Every result you receive ties back to peer-reviewed research, not lifestyle marketing. The science is published, replicated, and clinical.

Reviewed in clinic

Validated by practitioners running it daily

The same results you receive at home are the results running inside 9,000+ clinics. Same science, same rigor, same recommendations.

**Frank Lipman, MD**Functional medicine pioneer

**Elizabeth W. Boham, MD, MS, RD**The UltraWellness Center

Practitioners, organizations, and professional sports teams

The 3X4 framework

Why a tailored approach works.

A "Genes First" approach provides a framework for tailored health management to improve healthspan and build lifelong resilience.

Genetics

Environment

Personal
Healthcare

How it works

From order to answers in three weeks.

Day 1–3

Order your kit

Ships free to your door, painless cheek swab, done in 60 seconds.

~ 5 minutes

Mail it back

No blood draw, no clinic. Drop the sealed sample in any mailbox with the prepaid label.

2–3 weeks

Lab analysis

Our CLIA-certified partner lab reads your DNA. Our science team integrates the markers into 35 biochemical pathway results.

Tailored genetics guidance in the 3X4 Health app

Lifetime access

Your genetics

Tailored food and lifestyle guidance, plus downloadable PDF results, yours for life in the 3X4 Health app

New in the 3X4 Health app

Your DNA, turned into a clear plan.

The Genes First™ Plan turns your results into a tailored plan for food, supplements, and lifestyle, built from the way your genetic pathways work together. Included with every test. No subscription, no upsell.

Get the 3X4 Genetics Test → Already tested? See your plan

Choose your kit

One test. Or another year of guesswork.

One-time payment. No subscription. HSA/FSA eligible.

3X4 Genetics Test + 3X4 Health app At-home DNA test, your genetic report tailored to you, and lifetime access to the 3X4 Health app. $299

Total $299

Free shipping · HSA/FSA eligible

Your genetics at a glance

Discover your foundation under every diet, supplement, and workout.

35 pathways across 10 health areas. Your focus areas. Your lower-priority ones. All of them valid for life, because your genes don't change.

Read your genes once
One guide, used for life
Know where to focus, and what to leave alone

ClickTap any result to see what it tests, and what you'll learn

Detoxification Inflammation Methylation Oxidative stress Mood & behaviour Memory Blood pressure Clotting Vascular health Cholesterol Appetite Pro-inflammatory fat Fat storage Energy Hormone balance Injury Endurance Power Recovery Training Response Detoxification Inflammation Methylation Oxidative stress Mood & behaviour Memory Blood pressure Clotting Vascular health Cholesterol Appetite Pro-inflammatory fat Fat storage Energy Hormone balance Injury Endurance Power Recovery Training Response

Glucose & insulin Muscle health Collagen & joints Bone health Caffeine Salt Iron Gluten Histamine Vitamin B12 Folate Choline Vitamin C Vitamin D Fatty acids Glucose & insulin Muscle health Collagen & joints Bone health Caffeine Salt Iron Gluten Histamine Vitamin B12 Folate Choline Vitamin C Vitamin D Fatty acids

Some results are lower priority, you can leave them alone. Some need attention from day one. All 35 stay valid for life, because your genes don't change.

Why, not just what

There's a better alternative to guesswork.

Real questions, and what your genetics reveal about them.

I'm always exhausted, even after a full night's sleep. Why?

Energy isn't only about how long you sleep, it's about how your cells produce it. Your Energy, Mitochondria, and Oxidative stress results show where your biology drains and where it can be refuelled, so you stop chasing a coffee at 3pm and start fixing the wiring underneath it.

Your result might look like Your mitochondria produce plenty of energy, but high oxidative stress wears them down faster than they recover, so you feel drained even after a full night's sleep. Prioritise antioxidant-rich foods, the B-vitamins your cells use to produce energy, and steady sleep to protect recovery.

My sleep tracker says I slept fine. So why don't I wake up rested?

Sleep that looks fine on a tracker isn't always fine in your biology. Your Caffeine, Methylation, and Mood & behaviour results shape how your nervous system winds down, and what keeps it switched on. Match your evening to the chemistry you actually have, not the chemistry a podcast told you to fix.

Your result might look like You metabolise caffeine very slowly. Last coffee by 11am, magnesium glycinate in the evening, and a hard light cut-off at 9pm will do more for your sleep than any tracker setting.

My migraines come and go. Is there something my genes can tell me?

Migraine triggers usually live in the same biology 3X4 reads, Inflammation, Methylation, Histamine, and Caffeine. Knowing where your sensitivities sit narrows the trigger list from "everything" to "these three."

Your result might look like You clear histamine slowly (DAO low). Aged cheese, red wine, fermented foods, and cured meats are likely amplifying your trigger load. A 2-week low-histamine elimination is the cheapest experiment you can run.

Why do I feel like I'm always one hard workout away from burnout?

Your Inflammation, Oxidative stress, and Muscle health results set your real recovery ceiling. Train with your biology, not against it, and the same workout that flattens you today becomes a workout you can repeat tomorrow.

Your result might look like Your inflammation switch runs hot. Eat omega-3-rich foods daily, oily fish, chia seeds, and walnuts, and use physical therapy techniques like contrast showers or massage weekly to support recovery.

I eat well and exercise. Why is weight management still a constant struggle?

Your Appetite, Fat storage, and Pro-inflammatory fat results shape how your body responds to food long before willpower enters the room. The plate that works for you reflects your biology, not generic macro rules.

Your result might look like Your leptin signal arrives late. Add bitter-tasting foods like arugula or radicchio, with olive oil, to your daily diet to boost GLP-1 levels and reduce hunger.

Am I really getting the most from the supplements I take?

A good chunk of typical supplement stacks treat needs your body never had. Your Nutrients results show which vitamins you convert efficiently and which ones your biology genuinely struggles with, so you stop guessing and start buying only what you need.

Your result might look like You likely have a high requirement for vitamin D. Ensure daily sunlight exposure, vitamin D-rich foods, and consider a vitamin D3 supplement, and skip the supplements your biology never needed.

Get the only health test you'll buy once.

Get my DNA kit →

One-time payment · Lifetime app access · HSA/FSA eligible · Free shipping

One test. A lifetime of answers