One test.
A lifetime of answers Less than a penny a day, for life.

The same diet keeps failing you. Your energy crashes at the same time every afternoon. Your supplement shelf grows but nothing actually changes. 3X4 reads your DNA once and turns it into a plain-English guide for the 9 health areas that drive how you feel — energy, sleep, weight, hormones, and more. Not predictions. Not ancestry. A guide for how your body actually works.

Get my DNA kit → See a sample report

For energy, sleep, weight, hormones & more · 8,000+ practitioners worldwide · HSA/FSA eligible

CLIA-certified

Partner lab

8,000+

Practitioners worldwide

2–3 wks

Results turnaround

HSA / FSA

Eligible

Your genetics at a glance

Discover your foundation under every diet, supplement, and workout.

30 pathways across 9 health areas. Your focus areas. Your lower-priority ones. All of them valid for life — because your genes don't change.

Read your genes once
One guide, used for life
Know where to focus — and what to leave alone

ClickTap any result to see what it tests — and what you'll learn

Detoxification Inflammation Methylation Oxidative stress Mood & behaviour Memory Blood pressure Clotting Vascular health Cholesterol Appetite Pro-inflammatory fat Fat storage Energy Hormone balance Detoxification Inflammation Methylation Oxidative stress Mood & behaviour Memory Blood pressure Clotting Vascular health Cholesterol Appetite Pro-inflammatory fat Fat storage Energy Hormone balance

Glucose & insulin Muscle health Collagen & joints Bone health Caffeine Salt Iron Gluten Histamine Vitamin B12 Folate Choline Vitamin C Vitamin D Fatty acids Glucose & insulin Muscle health Collagen & joints Bone health Caffeine Salt Iron Gluten Histamine Vitamin B12 Folate Choline Vitamin C Vitamin D Fatty acids

Some results are lower priority — you can leave them alone. Some need attention from day one. All 30 stay valid for life, because your genes don't change.

Real people, real reasons

Whatever brought you here, your DNA meets you there.

Performance, balance, parenting, or the long game — 3X4 reads the same genes and turns them into a plan that fits the reason you came.

Jenna
“Turns out my DNA had the answers I was missing.”
Leslie
“I wasn’t dealing with multiple health issues — I was dealing with one story I didn’t know how to read yet.”
Grace
“How cool would it be if our bodies came with an instruction manual?”
Candice
“You don’t look at the symptoms — you look upstream.”
Brian Mazza
“It’s not about guessing anymore — it’s about knowing.”
Dr Perlmutter
“When we understand our uniqueness, we’re really a leg up for longevity.”
Dr Becky
“Your body runs on entire biological pathways, not isolated genes.”

Used in clinic, taken at home

The test 8,000+ clinicians trust.

3X4 is not a consumer-genetics product looking for a market. It is the test medical doctors, registered dietitians, and nutrigenomics specialists run with their patients, and on themselves, every day. Adopted in clinic before it ever reached your inbox.

3X4 is used in clinic across all 50 states. Darker shading marks where adoption runs highest.

8,000+Practitioners

50US states

6Countries

CLIA-certified

Run by a clinical-grade partner lab

Your sample is processed by a CLIA-certified laboratory, the same accreditation standard your physician's bloodwork is held to.

25+ years of research

Built on peer-reviewed nutrigenomics

Every result you receive ties back to peer-reviewed research, not lifestyle marketing. The science is published, replicated, and clinical.

Reviewed in clinic

Validated by practitioners running it daily

The same results you receive at home are the results running inside 8,000+ clinics. Same science, same rigor, same recommendations.

Clinician-reviewed

Built and reviewed by medical experts

Every result we report is developed and reviewed by practicing doctors and registered dietitians, the same experts who run 3X4 with their own patients every day.

**Frank Lipman, MD**Functional medicine pioneer

**Elizabeth W. Boham, MD, MS, RD**The UltraWellness Center

Practitioners, organizations, and professional sports teams

In plain English

Three examples of what your DNA actually says.

Each of your 30 pathways works the same way: we read the genetic markers, do the synthesis, and tell you exactly what to do. Here's what that looks like.

Caffeine · Sensitivities

Why your afternoon coffee is wrecking your sleep.

How fast your body clears caffeine. How sensitive your nervous system is to it. Three genetic markers, one result.

Your result might look like

You metabolize caffeine very slowly. The ergogenic kick from coffee arrives late and lingers. High or late-day intake disrupts your sleep architecture even when you don't feel "wired."

→ Cap caffeine at 11am. Match your last cup to your training window.

Vitamin D · Nutrients

Why you're under-replete even with daily sunshine.

Vitamin D is a vital nutrient, involved in multiple biochemical pathways essential for heart, bone, and brain health.

Your result might look like

You likely have a high requirement for vitamin D. Even adequate sun exposure may leave your levels lower than they should be.

→ Ensure daily sunlight exposure, vitamin D-rich foods, and consider a vitamin D3 supplement to help support your levels.

Methylation · Cellular

Why your mood, focus, and energy run through the same gene.

Methylation might sound technical, but it's a process happening every second — keeping your DNA stable, hormones balanced, brain chemistry in check, and energy steady.

Your result might look like

Your cells may have a hard time with methylation, which impacts how efficiently they carry out their functions. When it's off, mood, focus, and how energized you feel all take a hit.

→ Eat a variety of vitamin B-rich foods daily — leafy greens, avocados, or eggs — or consider a vitamin B-complex supplement.

See all 30 pathways in a sample report →

The 3X4 framework

Why personalization works.

A "Genes First" approach provides a framework for personalized health management to improve healthspan and build lifelong resilience.

Genetics

Environment

Personalized
Healthcare

How it works

From order to answers in three weeks.

Day 1–3

Order your kit

Ships free to your door — painless cheek swab, done in 60 seconds.

~ 5 minutes

Mail it back

No blood draw, no clinic. Drop the sealed sample in any mailbox with the prepaid label.

2–3 weeks

Lab analysis

Our CLIA-certified partner lab reads your DNA. Our science team integrates the markers into 30 biochemical pathway results.

Personalized genetics in the 3X4 Health app

Lifetime access

Your genetics

Personalized food and lifestyle guidance — plus downloadable PDF results — yours for life in the 3X4 Health app

Choose your kit

One test. Or another year of guesswork.

One-time payment. No subscription. HSA/FSA eligible.

3X4 Test + 3X4 Health app At-home DNA test, your personalized genetic report, and lifetime access to the 3X4 Health app. $299

Total $299

Free shipping · HSA/FSA eligible

Why, not just what

There's a better alternative to guesswork.

Real questions, and what your genetics reveal about them.

I'm always exhausted, even after a full night's sleep. Why?

Energy isn't only about how long you sleep — it's about how your cells produce it. Your Energy, Mitochondria, and Oxidative stress results show where your biology drains and where it can be refuelled — so you stop chasing a coffee at 3pm and start fixing the wiring underneath it.

Your result might look like Your mitochondria produce plenty of energy, but high oxidative stress wears them down faster than they recover — so you feel drained even after a full night's sleep. Prioritise antioxidant-rich foods, the B-vitamins your cells use to produce energy, and steady sleep to protect recovery.

My sleep tracker says I slept fine. So why don't I wake up rested?

Sleep that looks fine on a tracker isn't always fine in your biology. Your Caffeine, Methylation, and Mood & behaviour results shape how your nervous system winds down — and what keeps it switched on. Match your evening to the chemistry you actually have, not the chemistry a podcast told you to fix.

Your result might look like You metabolise caffeine very slowly. Last coffee by 11am, magnesium glycinate in the evening, and a hard light cut-off at 9pm will do more for your sleep than any tracker setting.

My migraines come and go. Is there something my genes can tell me?

Migraine triggers usually live in the same biology 3X4 reads — Inflammation, Methylation, Histamine, and Caffeine. Knowing where your sensitivities sit narrows the trigger list from "everything" to "these three."

Your result might look like You clear histamine slowly (DAO low). Aged cheese, red wine, fermented foods, and cured meats are likely amplifying your trigger load. A 2-week low-histamine elimination is the cheapest experiment you can run.

Why do I feel like I'm always one hard workout away from burnout?

Your Inflammation, Oxidative stress, and Muscle health results set your real recovery ceiling. Train with your biology, not against it — and the same workout that flattens you today becomes a workout you can repeat tomorrow.

Your result might look like Your inflammation switch runs hot. Eat omega-3-rich foods daily — oily fish, chia seeds, and walnuts — and use physical therapy techniques like contrast showers or massage weekly to support recovery.

I eat well and exercise. Why is weight management still a constant struggle?

Your Appetite, Fat storage, and Pro-inflammatory fat results shape how your body responds to food long before willpower enters the room. The plate that works for you reflects your biology — not generic macro rules.

Your result might look like Your leptin signal arrives late. Add bitter-tasting foods like arugula or radicchio, with olive oil, to your daily diet to boost GLP-1 levels and reduce hunger.

Am I really getting the most from the supplements I take?

A good chunk of typical supplement stacks treat needs your body never had. Your Nutrients results show which vitamins you convert efficiently and which ones your biology genuinely struggles with — so you stop guessing and start buying only what you need.

Your result might look like You likely have a high requirement for vitamin D. Ensure daily sunlight exposure, vitamin D-rich foods, and consider a vitamin D3 supplement — and skip the supplements your biology never needed.

Stop paying for guesses.

Less than a penny a day, for the rest of your life.

Supplements that may not be for you.

Most people spend hundreds a year on supplements their body may not need. 3X4 tells you which ones actually work for your genetics — and which ones to stop buying.

Diets that don't stick.

The average person tries multiple eating patterns before finding what works. 3X4 shows you the one your biology is actually built for — the first time.

Years lost to trial and error.

Most people spend years rotating through diets, supplements, and routines that were never built for their biology. 3X4 collapses that experiment cycle into one answer — the first time. And because it's HSA/FSA eligible, you can use pre-tax dollars to do it.