Supplements that may not be for you.
Most people spend hundreds a year on supplements their body may not need. 3X4 tells you which ones actually work for your genetics, and which ones to stop buying.
One test. A lifetime of clarity. Less than a penny a day, for life.
The same diet keeps failing you. Your energy crashes at the same time every afternoon. Your supplement shelf grows but nothing actually changes. 3X4 reads your DNA once and turns it into a plain-English guide for the 10 health areas that drive how you feel, energy, sleep, weight, hormones, and more. Not predictions. Not ancestry. A guide for how your body actually works.
- Read your genes once
- One guide, used for life
- Know where to focus, and what to leave alone
For energy, sleep, weight, hormones and more · 9,000+ practitioners worldwide · HSA/FSA eligible
Gladden Longevity · with Dr. Jeffrey Gladden
Your body runs on entire biological pathways, not isolated genes. Listeners take the 3X4 Genetics Test for $20 off with code GLADDEN20.
CAP & CLIA-certified
Partner lab
9,000+
Practitioners worldwide
2–3 wks
Results turnaround
HSA / FSA
Eligible
As heard onGladden Longevity
One test. $20 off for Gladden listeners.
One-time payment. No subscription. HSA/FSA eligible.
3X4 Genetics Test + 3X4 Health appAt-home DNA test, your tailored genetic report, and lifetime access to the 3X4 Health app.
GLADDEN20 takes $20 off the test, applied automatically at checkout
1
Product detailsYour code is applied automatically at checkout · Free shipping · HSA/FSA eligible
Or have an expert read it with you.
A one-on-one feedback session with an expert 3X4 Certified Practitioner, who walks you through your results and what to do first.
Test + 1:1 with a 3X4 Certified PractitionerEverything above, plus a one-on-one feedback session where an expert 3X4 Certified Practitioner walks you through your results and what to do first.
$599
one time
GLADDENBUNDLE applied automatically at checkout
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Product detailsEverything in the test, plus a one-on-one video consultation · Free shipping · HSA/FSA eligible
The test 9,000+ clinicians trust.
3X4 is not a consumer-genetics product looking for a market. It is the test medical doctors, registered dietitians, and nutrigenomics specialists run with their patients, and on themselves, every day. Adopted in clinic before it ever reached your inbox.
“This has allowed us to put genes first in our clinic, meaning all patients who come through our doors are required to do a 3X4 Genetics test so we can personalize their interventions. This is a game changer in personalized longevity medicine.”
“The 3X4 Genetics test panel is an invaluable tool to help determine where to focus in caring for our patients. By knowing each patient’s pathways, we can customize a treatment plan that helps our patients reach their health goals.”
Whatever brought you here, your DNA meets you there.
“Turns out my DNA had the answers I was missing.”
Jenna
“I wasn’t dealing with multiple health issues — I was dealing with one story I didn’t know how to read yet.”
Leslie
“How cool would it be if our bodies came with an instruction manual?”
Grace
“You don’t look at the symptoms — you look upstream.”
Candice
“It’s not about guessing anymore — it’s about knowing.”
Brian Mazza
“When we understand our uniqueness, we’re really a leg up for longevity.”
Dr Perlmutter
Discover your foundation under every diet, supplement, and workout.
35 pathways across 10 health areas. Your focus areas. Your lower-priority ones. All of them valid for life, because your genes don't change.
Cellular Health
Your cellular health underpins your energy, resilience, and overall well-being. You can take targeted steps to optimize energy production, reduce cellular damage, and support long-term health.
Brain Health
Your brain health drives emotional balance, focus, and memory. Based on your results, you’ll gain practical recommendations on nutrition, habits, and stress-management techniques to support emotional stability, mental clarity, and lasting brain adaptability.
Heart & Vascular Health
Your heart and circulation depend on finely tuned genetic controls. With these insights, you can make smarter choices around diet, movement, and lifestyle to support lifelong heart and circulation health.
Weight
Your body-weight biology is shaped by multiple genetic levers. Knowing where your unique levers lie lets you fine-tune nutrition, exercise, and lifestyle tactics to work with rather than against your biology for sustainable weight management.
Hormone Health
Hormones influence everything from mood and metabolism to sleep and stress resilience. Insight into your genetic predisposition helps you prioritize nutrition, lifestyle, and environmental choices that promote optimal hormone regulation and reduce the risk of imbalances.
Blood Sugar Regulation
Steady glucose and insulin are key to energy and metabolic health. Armed with your Glucose & Insulin profile, you can adopt targeted strategies, like meal timing, nutrient support, and daily movement to stabilize blood sugar and enhance long-term metabolic wellness.
Muscle & Skeletal Health
Your muscles, joints, and bones depend on genetic factors that influence strength, flexibility, and repair. These results help you identify areas where you may be more prone to tissue breakdown, connective damage, or lower bone turnover, so you can take proactive steps to strengthen your structure, reduce injury risk, and stay active for life.
Sensitivities
Your body’s reactions to common compounds can affect energy, digestion, and overall wellbeing. These insights empower you to adjust your diet and environment, avoiding or moderating specific exposures, to reduce discomfort and support overall wellness.
Nutrients
Genes affect how you absorb, use, and transport key vitamins and fats. Knowing where you have higher needs or lower efficiency lets you tailor your diet and supplementation to support energy, immunity, brain health, and cellular function.
Activity
Your genetics shape how your body moves, builds resilience, and recovers. Across five activity pathways, injury, endurance, power, recovery, and training response, you'll see how to train smarter, protect against injury, and recover better for your unique biology.
Every pathway result explains what it means for you, with food, lifestyle and supplement guidance built for your genes.
From order to answers in three weeks.
01
/ 04
Order your kit
Ships free to your door, painless cheek swab, done in 60 seconds.
Day 1–3
02
/ 04
Mail it back
No blood draw, no clinic. Drop the sealed sample in any mailbox with the prepaid label.
~ 5 minutes
03
/ 04
Lab analysis
Our CAP & CLIA-certified partner lab reads your DNA. Our science team integrates the markers into 35 biochemical pathway results.
2–3 weeks
04
/ 04
Your 3X4 Health report
Your tailored 3X4 Health report, food and lifestyle guidance across all 35 pathways, plus downloadable PDF results, yours for life in the 3X4 Health app.
Lifetime access
Stop paying for guesses.
Less than a penny a day, for the rest of your life.
Diets that don't stick.
The average person tries multiple eating patterns before finding what works. 3X4 shows you the one your biology is actually built for, the first time.
Years lost to trial and error.
Most people spend years rotating through diets, supplements, and routines that were never built for their biology. 3X4 collapses that experiment cycle into one answer, the first time. And because it's HSA/FSA eligible, you can use pre-tax dollars to do it.
There's a better alternative to guesswork
I'm always exhausted, even after a full night's sleep. Why?
Energy isn't only about how long you sleep, it's about how your cells produce it. Your Energy, Mitochondria, and Oxidative stress results show where your biology drains and where it can be refuelled, so you stop chasing a coffee at 3pm and start fixing the wiring underneath it.
Your result might look like: Your mitochondria produce plenty of energy, but high oxidative stress wears them down faster than they recover, so you feel drained even after a full night's sleep. Prioritise antioxidant-rich foods, the B-vitamins your cells use to produce energy, and steady sleep to protect recovery.
My sleep tracker says I slept fine. So why don't I wake up rested?
Sleep that looks fine on a tracker isn't always fine in your biology. Your Caffeine, Methylation, and Mood & behaviour results shape how your nervous system winds down, and what keeps it switched on. Match your evening to the chemistry you actually have, not the chemistry a podcast told you to fix.
Your result might look like: You metabolise caffeine very slowly. Last coffee by 11am, magnesium glycinate in the evening, and a hard light cut-off at 9pm will do more for your sleep than any tracker setting.
My migraines come and go. Is there something my genes can tell me?
Migraine triggers usually live in the same biology 3X4 reads, Inflammation, Methylation, Histamine, and Caffeine. Knowing where your sensitivities sit narrows the trigger list from "everything" to "these three."
Your result might look like: You clear histamine slowly (DAO low). Aged cheese, red wine, fermented foods, and cured meats are likely amplifying your trigger load. A 2-week low-histamine elimination is the cheapest experiment you can run.
Why do I feel like I'm always one hard workout away from burnout?
Your Inflammation, Oxidative stress, and Muscle health results set your real recovery ceiling. Train with your biology, not against it, and the same workout that flattens you today becomes a workout you can repeat tomorrow.
Your result might look like: Your inflammation switch runs hot. Eat omega-3-rich foods daily, oily fish, chia seeds, and walnuts, and use physical therapy techniques like contrast showers or massage weekly to support recovery.
I eat well and exercise. Why is weight management still a constant struggle?
Your Appetite, Fat storage, and Pro-inflammatory fat results shape how your body responds to food long before willpower enters the room. The plate that works for you reflects your biology, not generic macro rules.
Your result might look like: Your leptin signal arrives late. Add bitter-tasting foods like arugula or radicchio, with olive oil, to your daily diet to boost GLP-1 levels and reduce hunger.
Am I really getting the most from the supplements I take?
A good chunk of typical supplement stacks treat needs your body never had. Your Nutrients results show which vitamins you convert efficiently and which ones your biology genuinely struggles with, so you stop guessing and start buying only what you need.
Your result might look like: You likely have a high requirement for vitamin D. Ensure daily sunlight exposure, vitamin D-rich foods, and consider a vitamin D3 supplement, and skip the supplements your biology never needed.
Get the only health test you'll buy once.
One cheek swab. Results in 2–3 weeks. A genetic guide that informs every health decision from here forward, for less than a penny a day, for life.
One test · Results in 2–3 weeks · HSA/FSA eligible